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Description
Tirzepatide: 20.2% in SURMOUNT-5 In the head-to-head SURMOUNT-5 trial, tirzepatide reached 20.2% average weight loss compared with 13.7% for semaglutide at 72 weeks
For someone at BMI 35 trying to reach BMI 28, tirzepatide may get them there
However, it can cause steatorrhea, resulting in fat-soluble vitamin deficiency, and can even cause liver damage
Dosing and How to Take Them Semaglutide Dosing For weight loss (Wegovy): Start: 0.25 mg weekly for 4 weeks Increase gradually to 2.4 mg weekly Take as injection under the skin once per week Also available as daily pill (Rybelsus) for diabetes Tirzepatide Dosing For weight loss (Zepbound): Start: 2.5 mg weekly for 4 weeks Can increase up to 15 mg weekly Take as injection under the skin once per week Only available as injection, not as pills Both medications work best when you increase the dose slowly
The tirzepatide clinical data consistently shows superior results in this range
Many patients achieve HbA1c levels below 7%, and a substantial proportion reach levels below 5.7%, which falls within the non-diabetic range
