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Sertraline, as a SSRIs, has an intrinsic antibacterial and antifungal activity in vitro, and it is capable of increasing antibacterial activities of antibiotics and making susceptible some previously resistant strains [262]

The average HbA1c reduction may have been attenuated by floor effect, as a high proportion of participants approached near-normal glycaemic levels

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Conducting studies with oral formulations might require more foundational research to establish optimal parameters, adding layers of complexity to experimental design