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Reduced food intake from GLP-1 therapy can compound nutrient depletion that breastfeeding naturally causes

Krista Savage RNC-MNN BSN IBCLC Lauren Covey MBA P4 Katie Boatler RN BSN Kaytlin Krutsch PhD PharmD MBA BCPS Resources: Diab H, Fuquay T, Datta P, Bickel U, Thompson J, Krutsch K

Energy and fatigue changes GLP-1 related fatigue affects approximately 11% of users in clinical trials, and it tends to recur with each medication change

A meta-analysis comparing the two compounds directly found retatrutide produced an average of 16.34 kg of weight loss compared to 11.82 kg for tirzepatide

Other Exclusions Pregnant or breastfeeding individuals are generally advised not to take Tirzepatide, as there is limited data on its safety in these groups

Over a year, 87.8% of participants in the tirzepatide group lost 5% or more of their body weight, compared to 71.8% of those in the semaglutide group
