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The GLP-1 Legacy gives clinicians something concrete to signpost towards

The current Wegovy prescribing information and current Zepbound prescribing information describe several overlapping concerns

Antithrombotic Effects GLP-1 agonists reduce cardiovascular events through several mechanisms previously summarized to include improved glycemic control, weight loss, lowering blood pressure, lipid lowering, reduced atherogenesis, attenuated vascular inflammation, improved endothelial cell function, vasodilation, and direct cardiovascular protective effects [88, 89]

Upon binding to their respective receptors on pancreatic beta cells, GIP and GLP-1 enhance insulin secretion in a glucose-dependent manner

Akasaki Y, Suematsu Y, Azushima K, Shiga Y, Sakima A, Satoh M, et al

However, these medications are not a standalone solution