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[DOI] [PubMed] [Google Scholar] 12.Rosenstock J, Allison D, Birkenfeld AL, et al

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Published data from these trials established tirzepatides influence on HbA1c, fasting glucose modulation, and body weight trajectories as significantly differentiated from existing single-receptor GLP-1 compounds

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GLP-1 receptor agonist exenatide attenuates the detrimental effects of obesity on inflammatory profile in testis and sperm quality in mice

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The mechanism here is multi-factorial: GLP-1R activation reduces hepatic lipogenesis, GIP receptor signalling improves peripheral fat handling, and GCGR activation promotes hepatic fatty acid oxidation directly

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