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The nations obesity rate has climbed in recent decades

It simply reduces medication exposure, which may lower receptor activation and make metabolic outcomes less predictable at doses that have not been studied in large clinical trials

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These central effects complement peripheral mechanisms and contribute to the overall gastric motility changes observed with GLP-1 RA therapy [16]

The association between obesity and HFpEF is largely independent of traditional risk factors, underscoring the importance of elucidating the nontraditional mechanistic pathways that connect these conditions and in that way to identify novel targets for HFpEF prevention and treatment