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5,6 GLP-1 treatments have also shown the ability to curb hunger, opening their potential use for obesity
demonstrated that semaglutide modulates the circulating proteome in individuals with overweight or obesity, with or without diabetes [67]

[96] [97] Novo Nordisk failed to pay a required patent maintenance fee, and their patent on the chemical structure of the drug expired in 2020

After a median follow-up of 3.2 years (duration of drug exposure 2.4 years) the primary outcome was reduced in the exenatide treated group, but this difference just missed achieving statistical significance (HR 0.91

Clinical trials have shown their efficacy and safety over several years, yet the possibility of long-term adverse effects remains a research focus
Given the fibrosis severity in this model, it is speculated that alleviation of liver fibrosis may lead to increased TG and TC levels (Fig.5-C, D)