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Sustainable nutrition habits and protein planning Resistance training to support muscle and metabolism Consistent sleep and stress-management strategies Behavior changes that can continue beyond medication use Ongoing medical follow-up and treatment adjustments Long-term perspective: The treatment plan should address both weight loss and how healthy, realistic results may be maintained

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As pointed out previously, 11,12 the cardiovascular benefit of the GLP-1 RAs is confined to long-acting agents, with no benefit from short-acting lixisenatide (Figure 1)