is golo a glp-1 Agonists - What it? GLP-1 side effects after 50:

J Clin Invest 2002;109:112531

GLP-1 receptor agonists: Targeting both hyperglycaemia and disease processes in diabetes

It plays several important roles in how your body manages energy: It signals your pancreas to release insulin when blood sugar rises It slows the rate at which food leaves your stomach, making you feel full longer It acts on the brains hunger centers to reduce appetite and food cravings It lowers glucagon, a hormone that triggers the liver to release stored sugar GLP-1 receptor agonists are medications that mimic and amplify these effects

Get more on your GLP-1 journey with Omada Food & Activity Coaching 2

LPS itself has multiple adverse effects on the gut function, promoting intestinal inflammation and disrupting tight junctions (TJ) organization via specific signaling pathways which determines directly enterocytes shedding without compensatory TJ- releasing, and induces oxidative stress in epithelial cells, mitochondrial failure, and mitophagy [22]

You have increased calorie intake and decreased calorie output, and that extra energy gets stored as adipose tissue