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This is referred to as metabolic adaptation, which reduces GLP-1 and GIP levels and increases the orexigenic hormone ghrelin

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Either GLP-1 or GIP potentiates glucose-dependent insulin response protecting -cells against cytokine-induced apoptosis or glucose [23]

Not by a weekly injection, but by compounds that have been part of the human diet for millennia

Back AAAS EurekAlert (18 Dec 2023) 'Toronto study identifies new concepts for GLP-1 action in the brain, the 2023 Science magazine breakthrough of the year'

Someone working in a highly regulated safety-sensitive industry has a different testing framework than someone in a standard office environment