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Older-generation compounds have benefited from years of manufacturing optimization and increased competition, leading to much lower market prices

Baseline comorbidities included distinct diagnosis of any of the following (yes, no): hypertension, hyperlipidemia, atrial fibrillation and flutter, deep vein thrombosis or pulmonary embolism, chronic heart failure, dementia, CKD stage, depression, anxiety, smoking, neuropathic pain, atherosclerotic cardiovascular disease (ASCVD), and additional weight or obesity-related conditions

#chronicpain #interventionalpainmanagement #medicaleducation #painmedicine Very interesting, it is very aligned with the experience I have in obese patients with MSK pain in which pain relief occurs before significant weight loss

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