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A patient who can afford and tolerate semaglutide for two years will have better outcomes than a patient who starts tirzepatide, hits financial or side effect barriers at month four, and discontinues

They are commonly associated with how these medications slow down digestion and affect appetite signals

These studies explored how GLP-1 agonists influence bone metabolism in an osteoporotic state, including effects on bone turnover markers, BMD, and fracture risk

However, the intestinal microbes that have been found as decreased in T2D in metagenomics studies are not traditional probiotics, and are being explored to produce next-generation probiotics (NGPs) (94, 95)

Metabolism 127 , 154937 (2022) I

This ensures weight loss is not just achieved, but maintained , with healthier behaviors embedded into daily life