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Semaglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist, is widely prescribed for weight loss in non-diabetic populations

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Pituitary hormone axes modulate glucose metabolism and exert direct or indirect effects on insulin secretion and function

Tirzepatide is a dual action GLP-1 and GIP receptor agonist

Subsequently, it was shown that weight loss caused an immediate decrease of pancreas fat only in people with type 2 diabetes and also that postprandial incretin spikes after bariatric surgery had no role in normalising fasting plasma glucose