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Patients with rheumatoid arthritis should not consider GLP-1 agonists as an alternative to established disease-modifying antirheumatic drugs (DMARDs) or biologic therapies

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While GLP-1 medications do not directly cause frequent urination, several indirect mechanisms may explain why some individuals notice changes in their urinary patterns after starting treatment

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Furthermore, earlier evaluations by NICE and HAS did not incorporate retreatment in their economic models, 26,27 and the Japanese HTA largely followed these international approaches