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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Kelly AS, Auerbach P, Barrientos-Perez M, Gies I, Hale PM, Marcus C, Mastrandrea LD, Prabhu N, Arslanian S NN8022-4180 Trial Investigators

Most patients experience identical outcomes on either formulation

Combining GLP-1 & GIP therapy with a personalized diet and exercise plan can improve blood pressure, diabetes markers, and cholesterol contributing to better long-term cardiovascular and metabolic health

The observed divergence in mortality results when comparing injectable semaglutide to sitagliptin (a placebo proxy) in benchmarking analyses led us to view the results for outcomes containing mortality with skepticism and focused our interpretation on the nonmortality clinical endpoints

When examining the individual components of the primary endpoint, we observed closely concordant results for myocardial infarction and stroke but divergent results for all-cause mortality, suggestive of residual confounding

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