glp-1 drugs mechanism of action of [25] Recent updates on GLP-1 agonists:

org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs Cleveland Clinic

Eberly LA, Yang L, Essien UR, et al

The superior cardioprotective effect of GLP-1 (7-36amide) relative to exendin-4 and the preservation of efficacy of GLP-1 (7-36amide) but not exendin-4 in GLP-1R KO mice suggest that some of the cardioprotective effects of GLP-1 (7-36amide) are independent of GLP-1R signaling and are potentially mediated via the DPP-4-cleaved GLP-1 metabolite GLP-1 (9-36amide) [201]

Its approved for weight loss in adults with obesity or overweight

FDA to Reduce LDL-C in Adults with Hypercholesterolemia

10.1016/j.molmet.2021.101180 Mol