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Therefore, the activation of the IGF-2/IGF-1R axis may contribute to -cell survival in response to GLP-1, and importantly, the increased IGF-2 secretion may be essential for triggering this response, as also observed in embryonic development (41)

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So then you sort of have an amplified effect inside the cell as well. Although all of these theories are interesting, they are just educated guesses at this point

Julius A, Hopper W

Bone and Joint Health Bone and joint health represent crucial aspects of overall well-being and mobility, particularly as individuals age