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40 Cholinergic inhibition of proinflammatory cytokine production is mediated through intracellular signal pathways downstream of 7nAChR that culminate in suppression of NF-B nuclear translocation (Figure 2)

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Membrane depolarization, triggered by a ligand-bound receptor, results in a spike of intracellular calcium (Ca 2+ ) which leads to the fusion of the endocrine granules with the lateral and the broader basal side, resulting in the discharge of a hormonal cargo in the capillaries of the mucosa

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