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This is slightly longer than the half-life of endogenous GLP-1, which has a half life of about 2 minutes, primarily via degradation by endogenous DPP-4

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"Liraglutide works by mimicking the hormone GLP-1, which regulates blood sugar and appetite," says Dr

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Berberine has been studied

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doi: 10.1210/jc.2003-030738

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It targets GLP-1, GIP, and glucagon receptors simultaneously, adding a third mechanism that directly increases energy expenditure and fat oxidation through the liver

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If you're seeing a psychiatrist or therapist, inform them about your GLP-1 treatment so they can assess whether mood changes represent a medication effect, interaction with psychiatric medications, or an independent condition requiring alternative management

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