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Consequently, other strategies for oral administration have been tested and developed, including (but not limited to) coadministration with enzyme inhibitors, structural modifications [cyclization, PEGylation, fatty acid conjugates of polypeptides (lipidization), fusing therapeutic proteins to cobalamin (vitamin B 12 )], and the use of delivery carriers or absorption enhancers

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Trimarco B., et al

doi: 10.1038/344879a0

Patients should inform healthcare providers about all supplements, including vitamins, minerals, herbs, and over-the-counter products, as comprehensive medication reconciliation is essential for safe tirzepatide therapy

Specifically, prolonged GLP-1RA administration (13 years or longer) has been associated with elevated thyroid cancer risk in certain populations [4], while high concentrations of liraglutide (100 nM) have been demonstrated to promote breast cancer progression via the NOX4/ROS/VEGF signaling pathway [18]

Clinicians must track glycemic control, manage side effects, and ensure proper medication use