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86 Plasma adiponectin levels are also regulated by insulin action as the increased adiposity induced by the anabolic effects of insulin reduces adiponectin secretion from adipocytes: circulating adiponectin levels are inversely correlated with adiposity

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Any patient on a TZD who presents with new or worsening lower extremity swelling warrants attention and, if unexplained by musculoskeletal causes, communication with the referring provider