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GLP-1 agonists are not exactly new, although this is a common misconception

The glucagon-like peptides: a new genre in therapeutic targets for intervention in Alzheimer's disease

I n the future, innovation will likely focus on five key areas: long-acting formulations, oral delivery methods, multi-target approaches, combination therapies, and expanding the range of indications

doi: 10.1016/j.diabres.2012.09.008 210 WenjingHShaoYYuYHuangWFengGLiJ

Disproportionality signals for IGE All five GLP-1RAs had statistically significant reporting odds ratios (RORs) for IGE: Semaglutide: ROR 24.8 Dulaglutide: ROR 14.7 Liraglutide: ROR 13.7 Exenatide: ROR 5.4 Tirzepatide: ROR 18.3 This analysis confirms that these drugs are significantly more likely to be reported in conjunction with IGE compared to other medications

2 A 10% to 20% reduction in basal insulin dose has been used in clinical trials