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BMI and Body Weight: GLP-1 RAs were associated with notable reductions in both body mass index (BMI) and body weight across a wide range of populations

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Several of the downregulated proteins are centrally implicated in cardiovascular and metabolic pathologies: TNFRSF11B (Osteoprotegerin) has been consistently associated with coronary artery calcification and vascular dysfunction and is known to be upregulated in human vascular smooth muscle cells predisposed to senescence and atherogenesis 6466

Right now, there is no clinical trial data to prove that starting with anything other than the FDA-approved regimen is safe

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