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Injection site reactions and other considerations Retatrutide is administered as a subcutaneous injection , typically in the abdomen, thigh, or upper arm

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Initial findings with liraglutide, using both in vitro and in vivo (animal models) GLP-1R assays, had shown it was challenging to achieve an optimal balance between a long plasma half-life and sufficiently high GLP-1R affinity in the presence of albumin ( * 20 g)