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Methods Study design and participants SURMOUNT-1 was a phase 3 randomised, double-blind, placebo-controlled trial in which adults with a body mass index (BMI) 30 kg/m 2 or 27 kg/m 2 and at least one weight-related complication, excluding diabetes, were assigned to once weekly, subcutaneous tirzepatide (5 mg, 10 mg or 15 mg) or placebo for 72 weeks as an adjunct to lifestyle intervention

GarauletMLeeYShenJParnellLArnettDTsaiMet alCLOCK genetic variation and metabolic syndrome risk: Modulation by monounsaturated fatty acids

GLP-1RAs are associated with reduced hepatic insulin resistance, which contributes to enhanced glucose homeostasis and improved metabolic profiles in patients with metabolic disorder syndrome (Lin et al., 2024)

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Oral Hygiene and Bacterial Control Brushing teeth and cleaning the tongue regularly helps remove bacteria that contribute to odour
