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Finally, while time-stratified and subgroup analyses provide valuable insights, they remain exploratory and should be interpreted with caution given the potential for multiple testing, limited power in certain strata, and the inherent arbitrariness of fixed time-windows

The expanding spectrum of G protein diseases

Or: Animal studies showed an adverse effect, but adequate and well-controlled studies in pregnant women failed to demonstrate fetal risk.CAnimal reproduction studies showed an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans