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A pilot randomized controlled trial found that exenatide, another GLP-1 receptor agonist, when used as an adjunct to nicotine patches, facilitated smoking cessation and reduced post-cessation weight gain

The lack of benefit with lixisenatide is likely attributable to its shorter half-life and more modest effects on glycemia and weight compared to longer-acting agonists

4.2 GLP-1-based agents The focus of GLP-1RA development has predominantly been on designing GLP-1 derivatives resistant to DPP-4 enzymatic activity and exhibiting slow renal clearance through chemical modification and pharmaceutical formulation

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Future studies should prioritize early PsA populations, ideally using stratified designs that incorporate metabolic profiling, to fully elucidate the dual immunomodulatory and metabolic potential of GLP-1RAs in altering disease trajectory

GLP-1 Agonists as a Complementary Tool: In contrast, while GLP-1 agonists can aid in reducing body weight and improving health markers, they are less likely to produce the transformative weight loss that is often necessary for significant disease resolution in morbidly obese patients