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Combining ashwagandha with semaglutide-based weight loss therapy requires careful consideration of how herbal adaptogens interact with GLP-1 receptor medications

Trial Registration The predefined protocol has been registered in PROSPERO having registration number of CRD42023473991

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While SELECT demonstrated compelling outcomes, stakeholders will likely look for further evidence to substantiate the benefits of weight management with Wegovy outside the controlled setting of a clinical trial, e.g., in real world studies to confirm effectiveness and safety in routine medical practice when treating large numbers of patients of greater diversity, or via the SELECT-LIFE extension study, which invites SELECT patients to participate in a 10-year observational follow-up to evaluate long-term benefits