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The STEP 1 trial showed average weight loss of 14.9% over 68 weeks

Then, there are other semaglutide drugs, such as Ozempic and Rybelsus

Buyer Takeaway: GLP-1 side effects are real, common during dose escalation, and worth discussing with your provider before your first dose

The arrival of orforglipron represents a significant step toward making effective weight management accessible to a broader population

For patients with insulin resistance or a semaglutide allergy, your doctor may suggest alternatives to GLP-1 anti-diabetic medications

18,22 Pharmacological intervention is therefore usually required to assist in long-term weight loss in obese patients, and there several available drugs for this but they often exhibit insufficient efficacy and dubious safety