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These concerns are especially important for people who are taking semaglutide for diabetes or weight management

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10.1124/jpet.108.147058 19 FalkD

The loss of HNF1A and FXYD2 may induce membrane hyperpolarization, thereby impairing insulin secretiona mechanism relevant to both maturity-onset diabetes of the young type 3 (MODY3) and T2D (Weng et al., 2023)

Mental health monitoring is important in younger patients, as some weight loss medications carry warnings about potential mood changes

Decreased hepatic glycogen content has been shown in preclinical models to contribute to insulin resistance and hepatic steatosis, two physiologic states directly implicated in diseases of metabolic dysfunction such as T2DM and obesity [94]