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Abstract The gastrointestinal hormones ghrelin and glucagon-like peptide-1 (GLP-1) have opposite secretion patterns, as well as opposite effects on metabolism and food intake

Ongoing monitoring: Regular check-ups allow healthcare providers to adjust dosages, monitor progress, and address any side effects or concerns

Peptide drugs have very recently been in the limelight because of the success of the Novo Nordisk blockbuster GLP-1 agonist Semaglutide (Ozempic, Figure 1)

Key considerations include the current thyroid status (active hyperthyroidism versus controlled euthyroid state), stability of thyroid function on treatment, presence of complications such as thyroid eye disease or cardiac manifestations, and the patient's overall metabolic health

And the use of DPP-4 inhibitors did not raise the risk of thyroid cancer compared with SGLT2 inhibitors or other treatment alternatives [113, 114]

BfR Health Assessment, 2006
