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For the placebo arm participants were started on: 1 metformin, 2 dapagliflozin (Supplementary Table 4)

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Autoimmune considerations : There is no evidence that GLP-1 receptor agonists worsen autoimmune thyroid disease or trigger new-onset Hashimoto's thyroiditis

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An FDA decision could be as early as 2027 based on estimated trial completion dates

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SAHPRA has already seized substantial quantities of illicit peptides, initiated formal criminal cases and referred licensed healthcare professionals caught distributing these substances to statutory bodies, including the Health Professions Council of South Africa (HPCSA) and the South African Pharmacy Council (SAPC)

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