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Based on a revised assumption that the risk of clinically significant RGV was 9.0% in the continue group and 0% in the hold group, the recalculated sample size of 116 patients remained close to the original estimate, so no adjustments to the original sample size were recommended

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Lastly, future directions include the development of clinically feasible GLP-1R antagonists, the identification of predictive biomarkers to guide patient selection and the integration of this approach into rational combinatorial immunotherapy regimens