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Multiple studies have demonstrated that water fasting for up to 21 days is well-tolerated [1, 2], although large studies on time frames longer than this have been limited and, to our knowledge, not incorporated the use of glucagon-like peptide-1 receptor agonists (GLP-1) for appetite suppression

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Proper hydration can influence the effectiveness of GLP-1 and vice versa

The underlying mechanisms of such HFD-induced systemic metabolic endotoxemia due to dysbiosis might involve low-grade intestinal inflammation and enhanced gut permeability [159]

Epidemiology and outcomes of hypoglycemia in patients with advanced diabetic kidney disease on dialysis: a national cohort study