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We note that the magnitude of weight loss in this study was less than that observed in the general population with obesity or overweight from the randomized trials of incretin-based weight loss medications with lifestyle that report roughly 816% average weight loss in 6 months after initiation [16, 17]

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This discovery provides an essential mechanistic blueprint to explain why patient responses vary, why weight loss eventually plateaus, and how combining treatments could extend drug efficacy

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FDA labeling includes warnings about pancreatitis, gallbladder disease, kidney injury related to dehydration, serious allergic reactions, diabetic retinopathy complications in some patients with diabetes, and possible thyroid C-cell tumor risk based on animal studies