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Groger G, Unger A, Holst JJ, Goebell H, and Layer P

Nonetheless, research focusing on their safety during pregnancy is scarce, with existing studies primarily addressing metabolic effects rather than gestational safety.224 Given that GLP-1/GIP dual agonists modulate multiple metabolic pathways, further research is necessary to elucidate their potential impact on fetal development.227 Additionally, safety assessments of GLP-1RAs and GLP-1/GIP dual agonists in non-pregnant women have identified common adverse reactions, including gastrointestinal discomfort and anorexia

Additionally, existing research has found that mushroom polysaccharides such as Amanita caesarea polysaccharide, Hericium erinaceus polysaccharide and Armillaria mellea polysaccharide could reduce AD through an antioxidant effect, which is mainly manifested as enhancing the Nrf2 cascade reaction

7 March 2024 Updates to text and Table 3 based on changes in the empagliflozin datasheet/indications (can now be used in renal impairment, and in children aged 10 years) 22 August 2023 Liraglutide information added