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10.3389/fendo.2019.00939 79 LienF.BerthierA.BouchaertE.GheeraertC.AlexandreJ.PorezG.et al (2014)

Take levothyroxine at your established time, separated from tirzepatide by maximum hours
Whether starting with microdose therapy or full-strength semaglutide, continuous use without planned discontinuation produces the most reliable weight maintenance outcomes supported by clinical evidence

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Very few people stay at maximum doses indefinitely
