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I usually start clients at 1.25 mg mounjaro twice per week without zofran honestly
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However, it contains a different medication (tirzepatide), and there is no oral version of Zepbound

Why have GLP-1 receptors historically been difficult to target with small molecules, and what has changed to make oral versions possible now

A proportion of participants in the retatrutide trial discontinued treatment due to gastrointestinal side effects that did not resolve

Additionally, while interest continues to grow, it is important to note that such compounds are typically classified as investigational in nature
