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Hunger returning to pre-treatment levels, reduced appetite suppression between injections, or cravings that interfere with your plan are also clinical indicators that dose adjustment deserves consideration

They both work by replacing the GLP1 hormone in our body that tells us that we feel full

The microdosing approach has gained significant traction in the compounded tirzepatide community

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This approach, consistent with FDA labeling recommendations for initial titration, may reduce the risk of gastrointestinal side effects in patients whose tolerance may have changed during the medication interruption

Potential trigger foods that may worsen symptoms include: Fatty and fried foods these delay gastric emptying further, compounding the GLP-1 effect Chocolate and mint both can relax the lower oesophageal sphincter Citrus fruits and tomatoes high acidity may irritate an already sensitive oesophagus Spicy foods capsaicin and other compounds can trigger reflux symptoms Carbonated beverages gas production increases gastric pressure Caffeine and alcohol both may worsen reflux through multiple mechanisms Potentially beneficial dietary choices include lean proteins (chicken, fish, turkey), whole grains, non-citrus fruits (bananas, melons, apples), vegetables (excluding tomatoes and onions), and low-fat dairy products