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Also a lot of residual confounding

10.1016/j.chemphyslip.2025.105510

Studies show that: Most people regain the lost weight within a year of stopping Appetite often returns in full force Digestive discomfort can linger Muscle loss may not be easily regained without structured refeeding and strength training Even when people continue with diet and exercise after stopping Ozempic, many experience a rebound effect

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Contrave side effects Common side effects of Contrave include : Nausea Constipation Headache Dizziness Insomnia Dry mouth Vomiting Diarrhea Less commonly, Contrave may cause serious side effects, such as increased blood pressure or heart rate, changes in mental health, seizures, and liver problems