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In relation to the clinical use of GLP-1R agonists for the treatment of PD, pharmacokineticpharmacodynamic correlations of each GLP-1R agonist, from relatively short acting exenatide (in the form of Byetta [twice daily] and sustained release Bydureon [once weekly]) to longer acting dulaglutide, should be closely examined as to their potency, selectivity, bloodbrain barrier (BBB) penetration, and tolerability, which may be very different from one another and ultimately impact their efficacy in PD

Cardiovascu- lar safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes

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Providers should still document BMI at treatment initiation, qualifying comorbidities, medication indication, and lifestyle intervention in the chart

They have not been reviewed by the FDA for safety, effectiveness, or quality before marketing and are not generic equivalents of FDA-approved branded medications such as Wegovy or Ozempic