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A clinically significant interaction exists between tirzepatide and oral contraceptives, with FDA labeling advising use of non-oral or backup contraception for 4 weeks after initiation and each dose increase

While these medications can offer powerful benefits, they do not replace the essential roles of a healthy diet and regular exercise

When combined with exercise and a healthy diet, they have been life-changing for many people with obesity and/or type 2 diabetes

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This is particularly critical for women of reproductive age: the former is more closely associated with alleviating chronic low-grade inflammation, while the latters loss would be detrimental to pregnancy and labor endurance and could compromise the stability of metabolic and nutritional reserves within the ART pathway