tamoxifen and glp 1 (Nolvadex): Uses, Side Effects, Alternatives & More Can You Take Ozempic with

Diamant M, Van Gaal L, Guerci B, Stranks S, Han J, Malloy J, et al

A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo

This strategy is more flexible and may offer potential additional benefits

Providers may determine that contraindications exist, alternative approaches would be more appropriate, medical justification is insufficient, or that medications are not medically indicated based on individual circumstances

It works on two hormonal pathways instead of one, which clinical trials have shown can produce greater weight loss compared to semaglutide alone

Hepatic impairment Neither medication requires dose adjustment for mild to moderate liver impairment