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However, in a subsequent cohort of diabetic patients treated for 5 weeks with liraglutide, activation of the OFC in response to food cues was increased, despite successful weight loss, improved metabolic profile, and reduced fat intake [36]

A few shifts stood out: RWE is moving from supporting evidence to decision-shaping input in formulary access Policy changes including CMS IRA drug price negotiations and Most Favored Nation pricing are creating secondary effects far beyond access and pricing, both in the US and globally Greater clarity is still needed on how evidence is interpreted regarding price negotiations in the US For Medical and Access teams, this is a signal to rethink how value is framed, evidenced, and communicated

Mounjaro is administered as a once-weekly subcutaneous injection , typically starting at a low dose (2.5 mg) and gradually titrated upwards to minimise gastrointestinal side effects

Veterans Affairs system earlier GLP-1 mental-health research has produced mixed results Generalizability is another issue