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Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol

GIP (glucose-dependent insulinotropic polypeptide) is a second gut hormone that also plays a role in fat storage, appetite and energy regulation

One such compound, exendin-4, has been shown to reduce drug-seeking behavior in rodents

High-quality proteins such as fish, poultry, eggs, dairy products, lean meats, and soy-based foods are excellent choices
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The medication does not directly damage anorectal tissue but may create conditions that facilitate haemorrhoid symptoms in predisposed individuals
