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It does not directly stimulate insulin secretion, making it a first-line agent for patients with insulin resistance

This approach is considered an off-label use

Drug Saf 2009;32:1931 [DOI] [PubMed] 47.van der Heijden PG, van Puijenbroek EP, van Buuren S, van der Hofstede JW

Safety and Tolerability Profile The safety profile of tirzepatide across clinical trials has been generally consistent with other incretin-based therapies

Most patients experience peak nausea and vomiting during weeks 14 after starting or increasing their dose, with significant improvement by week 6

At the same time, glycine is also an obligatory co-agonist at N-methyl-D-aspartate (NMDA) receptors, a type of excitatory glutamate receptor in the brain