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While semaglutide works powerfully on appetite and metabolism, its effects on brain chemistry can occasionally create emotional shifts

Sci Rep 13(1) Meloni AR, Deyoung MB, Lowe C, Parkes DG (2013) GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

Others notice significant reductions in body weight

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The US study reported a tendency towards decreasing risks for prostate cancer with increasing duration of GLP-1RA use [3]