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This gives your slowed-down digestive tract time to adjust to the new bulk

Mathew, MD , in an accompanying editorial comment

We still need to remember that: Lipedema fat is not normal fat. It does not respond to calorie restriction the way typical fat does

The proportion of patients in each treatment cohort who achieved clinically relevant weight loss (i.e., 5% [9]) was then evaluated

The AP is a circumventricular organ and plays important roles in central autonomic regulation

Taken together, all these issues make less weight loss an expected finding in SELECT, compared with STEP 1
