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Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease

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The primary endpoint was the time from randomization to a composite outcome consisting of the first occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke

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to explore the roles of DPP-4

In the United States, efforts are underway to alleviate supply constraints, but manufacturing capacity remains a limiting factor