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Prescribing approach Weekly injections for most GLP-1 protocols Start low, titrate based on response and side effects Ongoing monitoring with our clinical team in Oswego Contraindications (examples) We do not initiate GLP-1 therapy if you have, for example: Personal or family history of medullary thyroid cancer MEN 2 (Multiple Endocrine Neoplasia type 2) Pregnancy or plans to become pregnant History of pancreatitis or severe gastroparesis Full screening happens at consultation

[8] [9] The MHRA continues to monitor the safety profile of these medications as their use expands

[1] [13] However, according to the Ozempic Summary of Product Characteristics (SmPC), this effect has not been shown to reduce the clinical efficacy of commonly tested medications significantly

Results In this study, we included 168 pregnant women who were exposed to GLP1-RA during the first trimester of pregnancy

It usually resolves within a week or two as your body adapts

Conclusions We found no signal of disproportionate reporting of an association between GLP-1RA use and SSIBs